2-(2-phenyl-1,3-oxazol-4-yl)ethan-1-amine → HCID 67344658, compound

HRID 1397447Notes

Reaction equation

HRID 1397447 reaction equation
[C:1]1([C:7]2[O:8][CH:9]=[C:10]([CH2:12][CH2:13][NH2:14])[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:15][C:16]([F:32])([F:31])[C:17]1[O:21][N:20]=[C:19]([C:22]2[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=2)[C:25](O)=[O:26])[N:18]=1>>[C:1]1([C:7]2[O:8][CH:9]=[C:10]([CH2:12][CH2:13][NH:14][C:25](=[O:26])[C:24]3[CH:28]=[CH:29][CH:30]=[C:22]([C:19]4[N:18]=[C:17]([C:16]([F:32])([F:31])[F:15])[O:21][N:20]=4)[CH:23]=3)[N:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 180714182-(2-phenyl-1,3-oxazol-4-yl)ethan-1-amineHCID 251808543-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid

Product 1

HCID 67344658HCID 67344658, compoundYield 25%

Procedure

This compound was synthesized from 2-(2-phenyloxazol-4-yl)ethanamine and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described in example 8 step 6 (40 mgs, yield 25%). 1H NMR (CDCl3) δ 8.59 (s, 1H), 8.26 (d, J=7.8 Hz, 1H), 8.13 (d, J=8.1 Hz, 1H), 8.05 (m, 2H), 7.62-7.56 (m, 3H), 7.43 (m, 2H), 3.84 (m, 2H), 2.93 (m, 2H). MS (ESI) m/z: Calculated for C21H15F3N4O3: 428.11. found: 429.1 (M+H)+.

Sources & evidence

ORD record
ord-8552ad4c90a54020b717f6455943bfc6
Source dataset
uspto-grants-2014_12
Patent number
US08901156B2

Reaction notes

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