2-(2-phenyl-1,3-oxazol-4-yl)ethan-1-amine → HCID 67349844, compound

HRID 1397448Notes

Reaction equation

HRID 1397448 reaction equation
[C:1]1([C:7]2[O:8][CH:9]=[C:10]([CH2:12][CH2:13][NH2:14])[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:15][C:16]([F:32])([F:31])[C:17]1[O:21][N:20]=[C:19]([C:22]2[CH:23]=[N:24][CH:25]=[C:26]([CH:30]=2)[C:27](O)=[O:28])[N:18]=1>>[C:1]1([C:7]2[O:8][CH:9]=[C:10]([CH2:12][CH2:13][NH:14][C:27](=[O:28])[C:26]3[CH:30]=[C:22]([C:19]4[N:18]=[C:17]([C:16]([F:32])([F:31])[F:15])[O:21][N:20]=4)[CH:23]=[N:24][CH:25]=3)[N:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 180714182-(2-phenyl-1,3-oxazol-4-yl)ethan-1-amineHCID 673242165-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acid

Product 1

HCID 67349844HCID 67349844, compoundYield 32%

Procedure

This compound was synthesized from 2-(2-phenyloxazol-4-yl)ethanamine and 5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinic acid as described in example 8 step 6 (42 mgs, yield 32%). 1H NMR (CDCl3) δ 9.46 (d, J=2.1 Hz, 1H), 9.32 (d, J=2.1 Hz, 1H), 8.87 (t, J=2.7 Hz, 1H), 8.06-7.96 (m, 3H), 7.57-7.44 (m, 3H), 3.85 (m, 2H), 2.93 (t, J=6.3 Hz, 2H). MS (ESI) m/z: Calculated for C20H14F3N5O3: 429.10. found: 430.1 (M+H)+.

Sources & evidence

ORD record
ord-fc35eaa4178e4a668b09cbb18b2601be
Source dataset
uspto-grants-2014_12
Patent number
US08901156B2

Reaction notes

Loading…