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HRID1397534

反应详情

EQUATION

反应方程式

HRID 1397534 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：Cl.N[C@@H]1C[C@H](CO)[C@@H](O)[C@H]1O
HCID2734536

(1R,2S,3R,5R)-3-amino-5-(hydroxymethyl)cyclopentane-1,2-diol Hydrochloride

C6H14ClNO3

结构：Clc1nc(Cl)nc(N[C@H]2CCc3ccccc32)n1
HCID86618706

未命名化合物

PRODUCTS

生成物

1
结构：OC[C@H]1C[C@@H](Nc2nc(Cl)nc(N[C@H]3CCc4ccccc43)n2)[C@H](O)[C@@H]1O
HCID86618705

未命名化合物

收率 88%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

CONDITIONS

反应条件

温度
150 °C

PROCEDURE

实验过程

A mixture of 4,6-dichloro-N-[(1S)-2,3-dihydro-1H-inden-1-yl]-1,3,5-triazin-2-amine (735 mg, 2.61 mmol), (1R,2S,3R,5R)-3-amino-5-(hydroxymethyl)cyclopentane-1,2-diol hydrochloride (400. mg, 218 mmol), potassium carbonate (602 mg, 4.36 mmol) and 1,4-dioxane (3.60 mL) in a sealed tube was heated to 150° C. for 20 mins using MWI. Silica gel chromatography eluting with a gradient of 2 to 7% MeOH in DCM afforded the title compound as a white solid (750. mg, 88%). LC/MS: Rt=1.42 min, ES+ 392 (FA standard).

WORKUP

后处理

  1. washSilica gel chromatography eluting with a gradient of 2 to 7% MeOH in DCM