Dimethylamine → HCID 66797899, compound

HRID 1397589Notes

Reaction equation

HRID 1397589 reaction equation
[O:1]=[C:2]1[N:5]([C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7])[C@H:4]2[C:13]3[C:18]([CH2:19][C@@H:3]12)=[CH:17][CH:16]=[CH:15][CH:14]=3.[CH3:20][NH:21][CH3:22].C1COCC1>>[CH3:20][N:21]([CH3:22])[C:2]([C@@H:3]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C@@H:4]1[NH:5][C:6](=[O:7])[O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:1]

Participants

4

Reactant 3

HCID 674DimethylamineHCID 8028TetrahydrofuranHCID 66798165HCID 66798165, compound

Product 1

HCID 66797899HCID 66797899, compoundYield 91%

Procedure

To tert-butyl rel-(2aR,7bR)-2-oxo-2,2a,3,7b-tetrahydro-1H-indeno[1,2-b]azete-1-carboxylate (200 mg, 0.77 mmol) was added 2.00 M dimethylamine in THF (1.90 mL, 3.80 mmol) in the sealed tube, and the mixture was microwaved at 120° C. for 30 minutes. The reaction mixture was concentrated under vacuum, and then the residue was washed with small amount of hexane to give the title compound (226 mg, 91%) as a white solid.

Workup

  1. customthe mixture was microwaved at 120° C. for 30 minutes
  2. concentrationThe reaction mixture was concentrated under vacuum
  3. washthe residue was washed with small amount of hexane

Sources & evidence

ORD record
ord-e9f5b412d6954d0c85efdfcf5ca1f553
Source dataset
uspto-grants-2014_12
Patent number
US08901136B2

Reaction notes

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