HCID 86722011, compound → HCID 136253053, compound

HRID 1398057Notes

Reaction equation

HRID 1398057 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:19]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[O:26][CH3:27])[N:18]=[C:17]([CH:28]3[CH2:33][C:32]([CH3:35])([CH3:34])[O:31][C:30]([CH3:37])([CH3:36])[CH2:29]3)[CH:16]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd].CO>[CH3:27][O:26][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[N:19]1[C:15]([C:12]2[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=2)=[CH:16][C:17]([CH:28]2[CH2:33][C:32]([CH3:35])([CH3:34])[O:31][C:30]([CH3:37])([CH3:36])[CH2:29]2)=[N:18]1

Participants

4

Reactant 1

HCID 86722011HCID 86722011, compound

Product 1

HCID 136253053HCID 136253053, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Palladium on carbon catalyst (5%, 400 mg) and 5-(4-(benzyloxy)phenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)-1H-pyrazole (257.8 mg, 0.52 mmol) were taken in MeOH (10 mL) and stirred under a H2 atmosphere (balloon) for 18 h. The catalyst was removed by filtration and the solvent was removed under vacuum to give 211 mg (100%) of the title compound.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe solvent was removed under vacuum

Sources & evidence

ORD record
ord-a5abdf9b99e84b73850504ffba7acf12
Source dataset
uspto-grants-2014_12
Patent number
US08901314B2

Reaction notes

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