HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloro-4-nitrobenzene → 8-(2-Chloro-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloro-4-nitrobenzene | HCID 7443 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 1,4-Dioxa-8-azaspiro(4.5)decane | HCID 67435 | — |
| Reactant | 1,2-Difluoro-4-nitrobenzene | HCID 123053 | — |
| Product | 8-(2-Chloro-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane | HCID 35416775 | — |
Reaction Steps
The title compound 3.05 g (quantitative) was obtained in a manner similar to the Manufacturing Example 25 by use of 3,4-dichloronitrobenzene and 1,4-dioxa-8-azaspiro[4.5]decane, instead of 3,4-difluoronitrobenzene and N-methylpiperazine, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08901315B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-8e970d1fd0dd4f5baff2482b508cb77a |
| Source note | uspto-grants-2014_12 |