1,2-Dichloro-4-nitrobenzene → 8-(2-Chloro-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane

HRID 1398075Notes

Reaction equation

HRID 1398075 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1Cl.[O:12]1[C:16]2([CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)[O:15][CH2:14][CH2:13]1.FC1C=C([N+]([O-])=O)C=CC=1F.CN1CCNCC1>>[Cl:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1[N:19]1[CH2:20][CH2:21][C:16]2([O:15][CH2:14][CH2:13][O:12]2)[CH2:17][CH2:18]1

Participants

5

Reactant 4

HCID 74431,2-Dichloro-4-nitrobenzeneHCID 531671-MethylpiperazineHCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 1230531,2-Difluoro-4-nitrobenzene

Product 1

HCID 354167758-(2-Chloro-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane

Procedure

The title compound 3.05 g (quantitative) was obtained in a manner similar to the Manufacturing Example 25 by use of 3,4-dichloronitrobenzene and 1,4-dioxa-8-azaspiro[4.5]decane, instead of 3,4-difluoronitrobenzene and N-methylpiperazine, respectively.

Sources & evidence

ORD record
ord-8e970d1fd0dd4f5baff2482b508cb77a
Source dataset
uspto-grants-2014_12
Patent number
US08901315B2

Reaction notes

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