反应详情

To a suspension of 2.946 g (13.73 mmol) of 2-chloro-N-(4-nitrophenyl)acetamide in 30 mL of ethanol was added 3.31 mL (41.18 mmol) of 2-(methylamino)ethanol and the mixture was refluxed for 4 hours. After the reaction mixture was cooled to room temperature and condensed, then, the residue was treated with ethyl acetate. The organic layer was washed with water and dried over with anhydrous sodium sulfate. The solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol=40/1) to give 2.05 g (59%) of the title compound.

1. temperaturethe mixture was refluxed for 4 hours
2. customcondensed
3. washThe organic layer was washed with water
4. dry with materialdried over with anhydrous sodium sulfate
5. customThe solvent was removed under reduced pressure
6. customthe residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol=40/1)