Sodium Methoxide → 3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzonitrile

Participants

Reaction Conditions

Reaction Steps

To a mixture of 3-fluoro-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzonitrile (0.51 g) in DMF (10 mL) was added sodium methoxide (5M methanol solution, 1.51 mL) at room temperature, and the mixture was stirred at 50° C. for 2 hr. The reaction mixture was added to ice water, and the precipitated solid was collected by filtration, and washed with water to give the title compound (0.34 g).

Provenance & Evidence