Sodium Methoxide → 3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzonitrile

HRID 1398161Notes

Reaction equation

HRID 1398161 reaction equation
F[C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[N:10]1[CH:14]=[N:13][C:12]([CH3:15])=[N:11]1)[C:5]#[N:6].[CH3:16][O-:17].[Na+]>CN(C=O)C>[CH3:16][O:17][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[N:10]1[CH:14]=[N:13][C:12]([CH3:15])=[N:11]1)[C:5]#[N:6]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 666085023-fluoro-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzonitrile

Product 1

HCID 666082863-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzonitrile

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
50 °C

Procedure

To a mixture of 3-fluoro-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzonitrile (0.51 g) in DMF (10 mL) was added sodium methoxide (5M methanol solution, 1.51 mL) at room temperature, and the mixture was stirred at 50° C. for 2 hr. The reaction mixture was added to ice water, and the precipitated solid was collected by filtration, and washed with water to give the title compound (0.34 g).

Workup

  1. filtrationthe precipitated solid was collected by filtration
  2. washwashed with water

Sources & evidence

ORD record
ord-51eaa44d26ea4a2cb964758841b12b8e
Source dataset
uspto-grants-2014_12
Patent number
US08901309B2

Reaction notes

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