Hydrochloric Acid → 3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzohydrazide dihydrochloride

HRID 1398163Notes

Reaction equation

HRID 1398163 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:15]([NH:17][NH:18]C(OC(C)(C)C)=O)=[O:16])[CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[N:12][C:11]([CH3:14])=[N:10]1.[ClH:26]>CO>[ClH:26].[ClH:26].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][C:8]=1[N:9]1[CH:13]=[N:12][C:11]([CH3:14])=[N:10]1)[C:15]([NH:17][NH2:18])=[O:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66608920tert-butyl 2-{[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]carbonyl}hydrazinecarboxylate

Product 1

HCID 666077703-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzohydrazide dihydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of tert-butyl 2-{[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]carbonyl}hydrazinecarboxylate (0.22 g) in methanol (2 mL) was added hydrochloric acid (4-Methyl acetate solution, 1 mL) at room temperature, and the mixture was stirred at room temperature for 4 hr. The precipitated solid was collected by filtration, and washed with ethyl acetate to give the title compound (0.15 g).

Workup

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-dbe11192d0684b37a9d44c5011210165
Source dataset
uspto-grants-2014_12
Patent number
US08901309B2

Reaction notes

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