反应详情

温度

100 °C

To ethyl (3S)-2-(methylsulfanyl)-3-(3,4,5-trifluorophenoxy)-3,4,5,6-tetrahydropyridine-3-carboxylate (702 mg) and 6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridine-2-carbohydrazide (500 mg) was added acetic acid (3 ml), and the mixture was stirred at 100° C. for 3 hr. The reaction mixture was diluted with ethyl acetate, and the mixture was washed with 10% aqueous potassium carbonate solution and saturated brine, dried over anhydrous sodium sulfate, and purified by silica gel column chromatography (NH, ethyl acetate). The crudely-purified product was purified by silica gel column chromatography (methanol/ethyl acetate) to give the title compound (1.02 g).

1. washthe mixture was washed with 10% aqueous potassium carbonate solution and saturated brine
2. dry with materialdried over anhydrous sodium sulfate
3. custompurified by silica gel column chromatography (NH, ethyl acetate)
4. customThe crudely-purified product was purified by silica gel column chromatography (methanol/ethyl acetate)