反应详情

A mixture of 4-fluoro-3-methoxybenzoic acid (2.33 g) and sulfuric acid (0.2 ml) in methanol (20 mL) was heated under reflux for 10 hr, and allowed to cool to room temperature. The reaction mixture was neutralized with saturated aqueous sodium hydrogen carbonate solution, the solvent was evaporated under reduced pressure, and water was added to the residue. The resultant precipitate was collected by filtration to give the title compound (2.31 g).

1. temperaturewas heated
2. temperatureunder reflux for 10 hr
3. customthe solvent was evaporated under reduced pressure, and water
4. additionwas added to the residue
5. filtrationThe resultant precipitate was collected by filtration