反应详情

To a mixture of 2-{(8R)-3-[6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl]-8-(3,4,5-trifluorophenoxy)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol (1.0 g) in 2-propanol (4 mL) was added a mixture of phosphoric acid (0.27 g) in 2-propanol (2 mL) at 50° C., and the mixture was stirred for 30 min. To the reaction mixture was added IPE (6 mL) at 50° C., and the mixture was stirred for 30 min. To the reaction mixture was added IPE (2 mL) at room temperature, and the mixture was stirred for 30 min. The crystals were collected by filtration, washed with IPE (2 mL) and dried to give the title compound (1.08 g).

1. additionwas added
2. additionTo the reaction mixture was added IPE (6 mL) at 50° C.
3. stirringthe mixture was stirred for 30 min
4. additionTo the reaction mixture was added IPE (2 mL) at room temperature
5. stirringthe mixture was stirred for 30 min
6. filtrationThe crystals were collected by filtration
7. washwashed with IPE (2 mL)
8. customdried