Methyl 2-(4-nitrophenoxy)propanoate → 2-(4-Nitrophenoxy)propanoic acid

HRID 1398254Notes

Reaction equation

HRID 1398254 reaction equation
C[O:2][C:3](=[O:16])[CH:4]([O:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=1)[CH3:5]>Cl>[N+:13]([C:10]1[CH:9]=[CH:8][C:7]([O:6][CH:4]([CH3:5])[C:3]([OH:16])=[O:2])=[CH:12][CH:11]=1)([O-:15])=[O:14]

Participants

3

Reactant 1

HCID 4501947Methyl 2-(4-nitrophenoxy)propanoate

Product 1

HCID 38051392-(4-Nitrophenoxy)propanoic acidYield 73.3%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 2-(4-nitrophenoxy)-propionic acid methyl ester (80 g) and concentrated hydrochloride acid (800 ml) was refluxed for 6 hours. The reaction mixture was cooled to room temperature. The product was filtered off and dried to obtain pure 2-(4-nitrophenoxy)-propionic acid (55 g) as a white powder with a melting point of 139-140° C.

Workup

  1. temperaturewas refluxed for 6 hours
  2. filtrationThe product was filtered off
  3. customdried

Sources & evidence

ORD record
ord-c4ed90f2d94a4c04a1c9dce067334d68
Source dataset
uspto-grants-2014_12
Patent number
US08901347B1

Reaction notes

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