反应详情

温度

0 °C

6 g (22.7 mmol) of 2-hydroxy-5-octanoylbenzoic acid and 12 mL (0.145 mol) of pyridine are dissolved in 15 mL of acetone. The medium is cooled to 0° C., and 12 mL (0.166 mol) of acetyl chloride are then added dropwise. After stirring for 15 hours at room temperature, water is added and the mixture is extracted with dichloromethane. The organic phase is dried over magnesium sulfate, filtered and then concentrated. 7 g of 2-acetyloxy-5-octanoylbenzoic acid are obtained in the form of a white solid in quantitative yield.

1. extractionthe mixture is extracted with dichloromethane
2. dry with materialThe organic phase is dried over magnesium sulfate
3. filtrationfiltered
4. concentrationconcentrated