Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | n-Octanoyl-5-salicylic acid | HCID 9838158 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 13748711 | HCID 13748711 | 100.7% |
Reaction Steps
6 g (22.7 mmol) of 2-hydroxy-5-octanoylbenzoic acid and 12 mL (0.145 mol) of pyridine are dissolved in 15 mL of acetone. The medium is cooled to 0° C., and 12 mL (0.166 mol) of acetyl chloride are then added dropwise. After stirring for 15 hours at room temperature, water is added and the mixture is extracted with dichloromethane. The organic phase is dried over magnesium sulfate, filtered and then concentrated. 7 g of 2-acetyloxy-5-octanoylbenzoic acid are obtained in the form of a white solid in quantitative yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08901357B2 |
|---|
| Source dataset | uspto-grants-2014_12 |
|---|
| ORD ID | ord-989611ec287841aa962bf3592c7b1ae5 |
|---|
| Source note | uspto-grants-2014_12 |
|---|
