反应详情

To a solution of methyl 4-(4-chloro-2-fluorophenyl)-6-methylnicotinate (700 mg, 2.50 mmol) in MeOH (5 mL) was added NaOH (200 mg, 7.51 mmol) in water (5 mL). The reaction mixture was stirred at room temperature for 2 h. The solvent was evaporated under reduced pressure and the residue obtained was adjusted to pH ˜3 by adding 1.5N HCl. The reaction mixture was extracted with dichloromethane. The organic phase was dried over Na2SO4, and concentrated under reduced pressure to afford 4-(4-chloro-2-fluorophenyl)-6-methylnicotinic acid (500 mg, 1.730 mmol, 92% crude yield) as white solid. The material was carried forward without further purification. LC/MS (ESI) m/e 266.0 [(M+H)+, calcd for C13H10ClFNO2 266.03]; LC/MS (Method I) tR=1.51 min.

1. customThe solvent was evaporated under reduced pressure
2. customthe residue obtained
3. extractionThe reaction mixture was extracted with dichloromethane
4. dry with materialThe organic phase was dried over Na2SO4
5. concentrationconcentrated under reduced pressure