Sodium Bicarbonate → HCID 178434210, compound

HRID 1398618Notes

Reaction equation

HRID 1398618 reaction equation
[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5](/[C:9](=[N:11]/[NH2:12])/[CH3:10])=[C:4](F)[CH:3]=1.C([O-])(O)=O.[Na+]>C(O)CO>[Br:1][C:2]1[CH:3]=[C:4]2[C:5]([C:9]([CH3:10])=[N:11][NH:12]2)=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 88861565(E)-1-(4-bromo-2,5-difluorophenyl)ethylidenehydrazine

Product 1

HCID 178434210HCID 178434210, compound

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Procedure

A solution of (E)-[1-(4-bromo-2,5-difluorophenyl)ethylidene]hydrazine in ethylene glycol (3 mL) was heated at 165° C. for 3 hours in a sealed tube. The mixture was cooled to RT and saturated NaHCO3 was added (3 mL) and stirred for 10 minutes. The mixture was filtered and solid was washed with water (5 mL×2) to obtain the desired product brown solid (163 mg, 62%).

Workup

  1. filtrationThe mixture was filtered
  2. washsolid was washed with water (5 mL×2)

Sources & evidence

ORD record
ord-f98666d4f79246418018fbf0d9bcad77
Source dataset
uspto-grants-2014_12
Patent number
US08901313B2

Reaction notes

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