huagongshe.com
HRID1398620

反应详情

EQUATION

反应方程式

HRID 1398620 的结构方程式

REACTANTS

反应物

2
结构：C#C[C@@](C)(O)c1nccs1
HCID58221813

未命名化合物

结构：Cc1nn(-c2ccnc(N)n2)c2cc(Br)c(F)cc12
HCID68182196

2-Pyrimidinamine, 4-(6-bromo-5-fluoro-3-methyl-1H-indazol-1-yl)-

C12H9BrFN5

PRODUCTS

生成物

1
结构：Cc1nn(-c2ccnc(N)n2)c2cc(C#C[C@@](C)(O)c3nccs3)c(F)cc12
HCID68181429

未命名化合物

PROCEDURE

实验过程

The title compound was prepared by the procedure described in Example 2-b by reacting 4-(6-bromo-5-fluoro-3-methylindazol-1-yl)pyrimidin-2-amine with (2R)-2-(1,3-thiazol-2-yl)but-3-yn-2-ol: 1H NMR (500 MHz, DMSO) delta 1.96 (3H, s), 2.55 (3H, s), 7.02 (3H, s), 7.15 (1H, br. s), 7.71 (1H, d, J=3.15 Hz), 7.79 (1H, s), 7.82 (1H, d, J=8.83 Hz), 8.26 (1H, d, J=5.52 Hz), 8.92 (1H, d, J=6.46 Hz); LC-MS m/z=+395.35 (M+H)+.