(r)-2-(Thiazol-2-yl)but-3-yn-2-ol → (2R)-4-[1-(2-aminopyrimidin-4-yl)-5-fluoro-3-methyl-1H-indazol-6-yl]-2-(1,3-thiazol-2-yl)but-3-yn-2-ol

Participants

Reaction Steps

The title compound was prepared by the procedure described in Example 2-b by reacting 4-(6-bromo-5-fluoro-3-methylindazol-1-yl)pyrimidin-2-amine with (2R)-2-(1,3-thiazol-2-yl)but-3-yn-2-ol: 1H NMR (500 MHz, DMSO) delta 1.96 (3H, s), 2.55 (3H, s), 7.02 (3H, s), 7.15 (1H, br. s), 7.71 (1H, d, J=3.15 Hz), 7.79 (1H, s), 7.82 (1H, d, J=8.83 Hz), 8.26 (1H, d, J=5.52 Hz), 8.92 (1H, d, J=6.46 Hz); LC-MS m/z=+395.35 (M+H)+.

Provenance & Evidence