反应详情

A solution of 4-[6-bromo-2-(trichloromethyl)-1H-1,3-benzodiazol-1-yl]pyrimidin-2-amine (500 mg, 1.23 mmol), 2-fluoroethan-1-ol (236 mg, 3.68 mmol) and cesium carbonate (1.2 g, 3.68 mmol) in N,N-dimethylformamide (3 mL) was stirred in a 20-mL sealed tube under nitrogen overnight at room temperature. The reaction mixture was diluted with 30 mL of water and the precipitate was collected by filtration to give 340 mg (79%) of 4-[6-bromo-2-(2-fluoroethoxy)-1H-1,3-benzodiazol-1-yl]pyrimidin-2-amine as a yellow solid; LC-MS: m/z=+352 (M+H)+.

1. customsealed tube under nitrogen overnight at room temperature
2. filtrationthe precipitate was collected by filtration