反应详情

To a solution of 4-{2-methyl-6-[2-(trimethylsilyl)ethynyl]-1,3-benzodiazol-1-yl}-1,3,5-triazin-2-amine (90 mg, 0.279 mmol) in THF (1 mL) was added 1M TBAF in THF (0.33 mL, 0.33 mmol). The mixture was allowed to stand at RT for 1 hr, the mixture was concentrated in vacuo and purified by column chromatography (Biotage 5-8% MeOH/DCM) to give the title compound; LC-MS: m/z+250.95 (M+H)+.

1. concentrationthe mixture was concentrated in vacuo
2. custompurified by column chromatography (Biotage 5-8% MeOH/DCM)