反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
2d was synthesized the condensation of 3, 4, 5-tris(benzyloxy)benzoic acid (480 mg, 1.09 mmol) and tryptamine hydrochloride (256 mg, 1.308 mmol) using standard EDC coupling method. 2d was isolated as white solid (482 mg, 76%) by elution with 0.5% methanol in chloroform. Rf: 0.538 (1.5% methanol in chloroform); mp: 105-107° C.; IR (neat) νmax 3413.77, 1637.45, 1579.59, 1496.66; 1H NMR (300 MHz, CDCl3) δ 2.96 (t, J=6.14 Hz, 2H), 3.63 (t, J=6.2 Hz, 2H), 4.89 (s, 4H), 4.96 (s, 2H), 6.08 (bs, 1H), 6.85 (S, 3H), 6.87-7.25 (m 18H), 7.54 (d, J=7.5 Hz, 1H), 8.21 (bs, 1H); 13C NMR (75 MHz, CDCl3) δ 24.90, 40.65, 71.01 (2C), 75.05, 106.44 (2C), 111.39, 118.48, 119.36, 121.98, 122.30, 126.86, 127.44 (6C), 127.88, 128.09, 128.40 (6C), 128.48, 129.97, 136.33, 136.56 (2C), 137.31, 140.69, 140.92, 152.54 (2C), 167.12; MS (ESI) m/z calcd. for C38H34N2O4: 582.25. found: 605.07 [M+Na]+.
WORKUP
后处理
- custom2d was synthesized