HCID 86632904, compound → HCID 68735949, compound

HRID 1398898Notes

Reaction equation

HRID 1398898 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[C:5]([NH:11][CH2:12][CH2:13][CH2:14][OH:15])=[C:4]([N+:16]([O-])=O)[CH:3]=1>O1CCCC1.[Pd]>[NH2:16][C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[C:6]([NH2:8])[C:5]=1[NH:11][CH2:12][CH2:13][CH2:14][OH:15]

Participants

4

Reactant 1

HCID 86632904HCID 86632904, compound

Product 1

HCID 68735949HCID 68735949, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 3-[(4-fluoro-2,6-dinitrophenyl)amino]propan-1-ol (3.59 g, 13.8 mmol) in tetrahydrofuran (140 mL) was stirred in the presence of 10% palladium on carbon (50% wet; 720 mg) under'hydrogen atmosphere at room temperature for 1.5 h. The catalyst was removed by filtration, and the filtrate was concentrated in vacuo to give the title compound as a pale brown oil (2.75 g, 13.8 mmol, 100%).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-8539c31e68bb4624b76ee5bc5f878ad0
Source dataset
uspto-grants-2014_12
Patent number
US08901141B2

Reaction notes

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