反应详情

温度

40 °C

Lithium borohydride (74.3 mg, 3.41 mmol) was added to a stirred solution of methyl 9-chloro-1-[6-(dimethylamino)-2-methylpyridin-3-yl]-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole-6-carboxylate (341 mg, 0.853 mmol) in tetrahydrofuran (5.0 mL) at room temperature, and the mixture was stirred at 40° C. for 20 hr. The reaction was quenched by aqueous saturated ammonium chloride at 0° C., concentrated in vacuo and the precipitate was collected by filtration, washed with water, diisopropyl ether to give the title compound as a colorless powder (317 mg, 0.853 mmol, 100%).

1. customThe reaction was quenched by aqueous saturated ammonium chloride at 0° C.
2. concentrationconcentrated in vacuo
3. filtrationthe precipitate was collected by filtration
4. washwashed with water, diisopropyl ether