Potassium Carbonate → HCID 44156374, compound

HRID 1399302Notes

Reaction equation

HRID 1399302 reaction equation
C([O:4][CH:5]([C:8]1[C:13]2[N:14]3[CH2:20][CH2:19][CH2:18][N:17]([C:21]4[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=4[Cl:28])[C:15]3=[N:16][C:12]=2[C:11]([Cl:29])=[CH:10][CH:9]=1)[CH2:6][CH3:7])(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[Cl:29][C:11]1[C:12]2[N:16]=[C:15]3[N:17]([C:21]4[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=4[Cl:28])[CH2:18][CH2:19][CH2:20][N:14]3[C:13]=2[C:8]([CH:5]([OH:4])[CH2:6][CH3:7])=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 441562551-[9-Chloro-1-(2,4-dichlorophenyl)-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazol-6-yl]propyl acetate

Product 1

HCID 44156374HCID 44156374, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of (−)-1-[9-chloro-1-(2,4-dichlorophenyl)-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazol-6-yl]propyl acetate (79.6 mg, 0476 mmol) in methanol (1.5 mL) was added potassium carbonate (36.4 mg, 0.264 mmol). The reaction mixture was stirred at room temperature for 1 hr. After the mixture was concentrated, the residue was diluted with water and extracted with ethyl acetate (×3). The combined organic layer was washed with brine (×1), dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with a 0-50% ethyl acetate/n-hexane gradient mixture. The resulting solid was recrystallized from ethyl acetate/n-hexane to give the title compound as a colorless powder (51.1 mg, 0.124 mmol, 71%).

Workup

  1. concentrationAfter the mixture was concentrated
  2. additionthe residue was diluted with water
  3. extractionextracted with ethyl acetate (×3)
  4. washThe combined organic layer was washed with brine (×1)
  5. dry with materialdried over anhydrous magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo
  8. customThe residue was purified by silica gel column chromatography
  9. washeluting with a 0-50% ethyl acetate/n-hexane gradient mixture
  10. customThe resulting solid was recrystallized from ethyl acetate/n-hexane

Sources & evidence

ORD record
ord-cefd3d47927d4378ada16f9ff68628a8
Source dataset
uspto-grants-2014_12
Patent number
US08901141B2

Reaction notes

Loading…