反应详情

温度

87.5 °C

A mixture of 2,2,2-trichloroethyl 2-(3-fluoro-4-nitrobenzamido)acetate (40 mg, 0.1 mmol), zinc dust (105 mg, 1.61 mmol) and AcOH (3 mL) was stirred at 85-90° C. for 15 min. The reaction mixture was attained to rt and diluted with EtOAc (30 mL). The solution was filtered through super cell and washed with EtOAc (2×5 mL). The residue obtained after evaporation of the solvent was chromatographed using chloroform:methanol (60:40) as eluents to give the product as an off-white color solid (17 mg, 75%), mp 198-200° C.

1. customwas attained to rt
2. filtrationThe solution was filtered through super cell
3. washwashed with EtOAc (2×5 mL)
4. customThe residue obtained
5. customafter evaporation of the solvent
6. customwas chromatographed