Sodium Hydroxide → 2-(4-(Azepan-1-yl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoic acid

HRID 1399629Notes

Reaction equation

HRID 1399629 reaction equation
[N:1]1([C:8]2[C:13]([CH:14]([CH2:19][CH2:20][CH3:21])[C:15]([O:17]C)=[O:16])=[C:12]([CH3:22])[N:11]=[C:10]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:9]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+]>CO>[N:1]1([C:8]2[C:13]([CH:14]([CH2:19][CH2:20][CH3:21])[C:15]([OH:17])=[O:16])=[C:12]([CH3:22])[N:11]=[C:10]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[N:9]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66956063Methyl 2-(4-(azepan-1-yl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoate

Product 1

HCID 669552002-(4-(Azepan-1-yl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoic acidYield 71.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-(azepan-1-yl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoate (0.084 g; 0.220 mmol), sodium hydroxide 10N solution (0.220 mL; 2.2 mmol) in methanol (2.2 mL) to afford 0.058 g (69%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-856c450657c14e01a28f6946cb902d5e
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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