Sodium Hydroxide → 2-(4-Methyl-6-(4-methylpiperazin-1-yl)-2-phenylpyrimidin-5-yl)pentanoic acid

HRID 1399631Notes

Reaction equation

HRID 1399631 reaction equation
[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([O:11]C)=[O:10])=[C:6]([N:16]2[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]2)[N:5]=[C:4]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:3]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([OH:11])=[O:10])=[C:6]([N:16]2[CH2:17][CH2:18][N:19]([CH3:22])[CH2:20][CH2:21]2)[N:5]=[C:4]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66955770Methyl 2-(4-methyl-6-(4-methylpiperazin-1-yl)-2-phenylpyrimidin-5-yl)pentanoate

Product 1

HCID 669559542-(4-Methyl-6-(4-methylpiperazin-1-yl)-2-phenylpyrimidin-5-yl)pentanoic acidYield 48%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-methyl-6-(4-methylpiperazin-1-yl)-2-phenylpyrimidin-5-yl)pentanoate (0.120 g; 0.314 mmol), sodium hydroxide 10N (0.314 mL; 3.14 mmol) in methanol (3 mL) to afford 0.055 g (48%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-fd3419389f4640b7a1ca6171af95fd37
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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