Sodium Hydroxide → 2-(4-(3,4-Dimethylphenyl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoic acid

HRID 1399633Notes

Reaction equation

HRID 1399633 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:9]2[C:14]([CH:15]([CH2:20][CH2:21][CH3:22])[C:16]([O:18]C)=[O:17])=[C:13]([CH3:23])[N:12]=[C:11]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[N:10]=2)[CH:5]=[CH:6][C:7]=1[CH3:8].[OH-].[Na+]>CO>[CH3:1][C:2]1[CH:3]=[C:4]([C:9]2[C:14]([CH:15]([CH2:20][CH2:21][CH3:22])[C:16]([OH:18])=[O:17])=[C:13]([CH3:23])[N:12]=[C:11]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[N:10]=2)[CH:5]=[CH:6][C:7]=1[CH3:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66955309Methyl 2-(4-(3,4-dimethylphenyl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoate

Product 1

HCID 669561122-(4-(3,4-Dimethylphenyl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoic acidYield 82.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-(3,4-dimethylphenyl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoate (0.083 g; 0.214 mmol), sodium hydroxide 10N (0.214 mL; 2.14 mmol) in methanol (2 mL) to afford 0.066 g (81%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-3c44842358564057af04e4744d7f2a02
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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