Sodium Hydroxide → 2-[4-Methyl-6-(2-naphthyl)-2-phenyl-pyrimidin-5-yl]pentanoic acid

HRID 1399635Notes

Reaction equation

HRID 1399635 reaction equation
[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([O:11]C)=[O:10])=[C:6]([C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:17]=2)[N:5]=[C:4]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:3]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([OH:11])=[O:10])=[C:6]([C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:17]=2)[N:5]=[C:4]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66955496Methyl 2-(4-methyl-6-(naphthalen-2-yl)-2-phenylpyrimidin-5-yl)pentanoate

Product 1

HCID 669558082-[4-Methyl-6-(2-naphthyl)-2-phenyl-pyrimidin-5-yl]pentanoic acidYield 92.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-methyl-6-(naphthalen-2-yl)-2-phenylpyrimidin-5-yl)pentanoate (0.090 g; 0.219 mmol), sodium hydroxide 10N (0.219 mL; 2.19 mmol) in methanol (2 mL) to afford 0.080 g (92%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-0ae9c2cd8a2a48ba88ec88c48836a039
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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