Sodium Hydroxide → 2-(4-(Benzofuran-5-yl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoic acid

HRID 1399639Notes

Reaction equation

HRID 1399639 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[C:15]([CH:16]([CH2:21][CH2:22][CH3:23])[C:17]([O:19]C)=[O:18])=[C:14]([CH3:24])[N:13]=[C:12]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[N:11]=3)=[CH:9][C:4]=2[CH:3]=[CH:2]1.[OH-].[Na+]>CO>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[C:15]([CH:16]([CH2:21][CH2:22][CH3:23])[C:17]([OH:19])=[O:18])=[C:14]([CH3:24])[N:13]=[C:12]([C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=4)[N:11]=3)=[CH:9][C:4]=2[CH:3]=[CH:2]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66955366Methyl 2-(4-(benzofuran-5-yl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoate

Product 1

HCID 669561092-(4-(Benzofuran-5-yl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoic acidYield 85.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-(benzofuran-5-yl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoate (0.114 g; 0.285 mmol), sodium hydroxide 10N (0.285 mL; 2.85 mmol) in methanol (3 mL) to afford 0.094 g (81%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-53a4c86dd932424fb9a5eece3d28da4b
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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