Sodium Hydroxide → HCID 66955372, compound

HRID 1399649Notes

Reaction equation

HRID 1399649 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]3[C:15]([CH:16]([CH2:21][CH2:22][CH3:23])[C:17]([O:19]C)=[O:18])=[C:14]([CH3:24])[N:13]=[C:12]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[N:11]=3)[CH:8]=2)[CH:3]=[CH:2]1.[OH-].[Na+]>CO>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]3[C:15]([CH:16]([CH2:21][CH2:22][CH3:23])[C:17]([OH:19])=[O:18])=[C:14]([CH3:24])[N:13]=[C:12]([C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=4)[N:11]=3)[CH:8]=2)[CH:3]=[CH:2]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66955687HCID 66955687, compound

Product 1

HCID 66955372HCID 66955372, compoundYield 52.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-(1H-indol-6-yl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoate (0.108 g; 0.270 mmol), sodium hydroxide 10N (0.270 mL; 2.7 mmol) in methanol (2.7 mL). Purification by flash-chromatography on silica gel using a gradient of methanol (1-10%) in dichloromethane furnished 0.055 g (52%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared
  2. customPurification by flash-chromatography on silica gel using a gradient of methanol (1-10%) in dichloromethane

Sources & evidence

ORD record
ord-7d9b79fb858440d8952ac01953ab7bb3
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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