Sodium Hydroxide → HCID 66955493, compound

HRID 1399653Notes

Reaction equation

HRID 1399653 reaction equation
[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([O:11]C)=[O:10])=[C:6]([C:16]2[CH:17]=[CH:18][C:19]3[N:24]([CH3:25])[CH2:23][CH2:22][O:21][C:20]=3[CH:26]=2)[N:5]=[C:4]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[N:3]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([OH:11])=[O:10])=[C:6]([C:16]2[CH:17]=[CH:18][C:19]3[N:24]([CH3:25])[CH2:23][CH2:22][O:21][C:20]=3[CH:26]=2)[N:5]=[C:4]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[N:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66956108Methyl 2-(4-methyl-6-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-2-phenylpyrimidin-5-yl)pentanoate

Product 1

HCID 66955493HCID 66955493, compoundYield 81.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-methyl-6-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-2-phenylpyrimidin-5-yl)pentanoate (0.075 g; 0.174 mmol), sodium hydroxide 10N (0.174 mL; 1.74 mmol) in methanol (1.7 mL) to afford 0.059 g (80%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-96d78278226945a8b99bcdf6094332cb
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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