Sodium Hydroxide → HCID 66955580, compound

HRID 1399657Notes

Reaction equation

HRID 1399657 reaction equation
[O:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]3[C:16]([CH:17]([CH2:22][CH2:23][CH3:24])[C:18]([O:20]C)=[O:19])=[C:15]([CH3:25])[N:14]=[C:13]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[N:12]=3)=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[OH-].[Na+]>CO>[O:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]3[C:16]([CH:17]([CH2:22][CH2:23][CH3:24])[C:18]([OH:20])=[O:19])=[C:15]([CH3:25])[N:14]=[C:13]([C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=4)[N:12]=3)=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66956022HCID 66956022, compound

Product 1

HCID 66955580HCID 66955580, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-(chroman-6-yl)-6-methyl-2-phenylpyrimidin-5-yl)pentanoate (0.094 g; 0.226 mmol), sodium hydroxide 10N (0.226 mL; 2.26 mmol) in methanol (2.2 mL) to afford 0.070 g (74%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-2f5497d1a939447b842fd7be9f28e6f9
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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