Sodium Hydroxide → HCID 66955960, compound

HRID 1399667Notes

Reaction equation

HRID 1399667 reaction equation
[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([O:11]C)=[O:10])=[C:6]([C:16]2[CH:25]=[CH:24][C:19]3[NH:20][C:21](=[O:23])[NH:22][C:18]=3[CH:17]=2)[N:5]=[C:4]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:3]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([OH:11])=[O:10])=[C:6]([C:16]2[CH:25]=[CH:24][C:19]3[NH:20][C:21](=[O:23])[NH:22][C:18]=3[CH:17]=2)[N:5]=[C:4]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66955574HCID 66955574, compound

Product 1

HCID 66955960HCID 66955960, compoundYield 13.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-methyl-6-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-phenylpyrimidin-5-yl)pentanoate (0.180 g; 0.432 mmol), sodium hydroxide 10N (0.432 mL; 4.32 mmol) in methanol (4.3 mL). Purification by preparative HPLC (HPLC method 2) furnished 0.024 g (13%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared
  2. customPurification by preparative HPLC (HPLC method 2)

Sources & evidence

ORD record
ord-8a3cdbac0d584d47829fbdc42d45a280
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

Loading…