Sodium Hydroxide → 2-(4-Methyl-6-(2-oxoindolin-6-yl)-2-phenylpyrimidin-5-yl)pentanoic acid

HRID 1399671Notes

Reaction equation

HRID 1399671 reaction equation
[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([O:11]C)=[O:10])=[C:6]([C:16]2[CH:24]=[C:23]3[C:19]([CH2:20][C:21](=[O:25])[NH:22]3)=[CH:18][CH:17]=2)[N:5]=[C:4]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:3]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([OH:11])=[O:10])=[C:6]([C:16]2[CH:24]=[C:23]3[C:19]([CH2:20][C:21](=[O:25])[NH:22]3)=[CH:18][CH:17]=2)[N:5]=[C:4]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66956203Methyl 2-(4-methyl-6-(2-oxoindolin-6-yl)-2-phenylpyrimidin-5-yl)pentanoate

Product 1

HCID 669555272-(4-Methyl-6-(2-oxoindolin-6-yl)-2-phenylpyrimidin-5-yl)pentanoic acidYield 2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-methyl-6-(2-oxoindolin-6-yl)-2-phenylpyrimidin-5-yl)pentanoate (0.066 g; 0.159 mmol), sodium hydroxide 10N (0.159 mL; 1.59 mmol) in methanol (1.5 mL). Purification by preparative HPLC (HPLC method 2) furnished 0.0012 g (2%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared
  2. customPurification by preparative HPLC (HPLC method 2)

Sources & evidence

ORD record
ord-ade927b3eb244786bd8d3d803fe4733e
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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