Sodium Hydroxide → HCID 50997323, compound

HRID 1399680Notes

Reaction equation

HRID 1399680 reaction equation
[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([O:11]C)=[O:10])=[C:6]([C:16]2[CH:17]=[C:18]3[C:22](=[CH:23][CH:24]=2)[CH2:21][CH2:20][C:19]3=[O:25])[N:5]=[C:4]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:3]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([OH:11])=[O:10])=[C:6]([C:16]2[CH:17]=[C:18]3[C:22](=[CH:23][CH:24]=2)[CH2:21][CH2:20][C:19]3=[O:25])[N:5]=[C:4]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 50997147HCID 50997147, compound

Product 1

HCID 50997323HCID 50997323, compoundYield 1.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-methyl-6-(3-oxo-2,3-dihydro-1H-inden-5-yl)-2-phenylpyrimidin-5-yl)pentanoate (0.177 g; 0.282 mmol), sodium hydroxide 10N (0.282 mL; 2.82 mmol) in methanol (2.8 mL). Purification by preparative HPLC (HPLC method 1) furnished 0.0016 g (1.4%) of the title compound as a brown solid.

Workup

  1. customThis compound was prepared
  2. customPurification by preparative HPLC (HPLC method 1)

Sources & evidence

ORD record
ord-62ca598d04c04ce1bb1ed4d00999c0ba
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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