Sodium Hydroxide → 4-Methoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)butanoic acid

HRID 1399691Notes

Reaction equation

HRID 1399691 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH:5]([C:10]1[C:11]([CH3:29])=[N:12][C:13]([N:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)=[N:14][C:15]=1[C:16]1[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=1)[C:6]([O:8]C)=[O:7].[OH-].[Na+]>CO>[CH3:1][O:2][CH2:3][CH2:4][CH:5]([C:10]1[C:11]([CH3:29])=[N:12][C:13]([N:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)=[N:14][C:15]=1[C:16]1[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=1)[C:6]([OH:8])=[O:7]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 50997143Methyl 4-methoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)butanoate

Product 1

HCID 509969724-Methoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)butanoic acidYield 40.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 4-methoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)butanoate (0.018 g; 0.045 mmol), sodium hydroxide 10N (0.045 mL; 0.45 mmol) in methanol (0.4 mL) to afford 0.007 g (38%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-801c8df4a33b4e538085fea8dc8b7d26
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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