Sodium Hydroxide → 2-(4-Methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-3-phenylpropanoic acid

HRID 1399695Notes

Reaction equation

HRID 1399695 reaction equation
[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:9]([O:11]C)=[O:10])=[C:6]([C:20]2[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=2)[N:5]=[C:4]([N:27]2[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)[N:3]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:9]([OH:11])=[O:10])=[C:6]([C:20]2[CH:21]=[CH:22][C:23]([CH3:26])=[CH:24][CH:25]=2)[N:5]=[C:4]([N:27]2[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]2)[N:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 50995547Methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-3-phenylpropanoate

Product 1

HCID 669556102-(4-Methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-3-phenylpropanoic acidYield 84.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-3-phenylpropanoate (0.087 g; 0.203 mmol), sodium hydroxide 10N (0.203 mL; 2.02 mmol) in methanol (2 mL) to afford 0.071 g (80%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-70712c0cacc74fb289e9b6ad1c1c7e8f
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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