HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-(4-Methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-3-phenylpropanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-3-phenylpropanoate | HCID 50995547 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(4-Methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-3-phenylpropanoic acid | HCID 66955610 | 84.2% |
Reaction Steps
This compound was prepared according to general method D from methyl 2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)-3-phenylpropanoate (0.087 g; 0.203 mmol), sodium hydroxide 10N (0.203 mL; 2.02 mmol) in methanol (2 mL) to afford 0.071 g (80%) of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08906906B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-70712c0cacc74fb289e9b6ad1c1c7e8f |
| Source note | uspto-grants-2014_12 |