Sodium Hydroxide → 3-Methyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoic acid

HRID 1399697Notes

Reaction equation

HRID 1399697 reaction equation
[CH3:1][CH:2]([CH2:28][CH3:29])[CH:3]([C:8]1[C:9]([CH3:27])=[N:10][C:11]([N:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)=[N:12][C:13]=1[C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=1)[C:4]([O:6]C)=[O:5].[OH-].[Na+]>CO>[CH3:1][CH:2]([CH2:28][CH3:29])[CH:3]([C:8]1[C:9]([CH3:27])=[N:10][C:11]([N:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)=[N:12][C:13]=1[C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=1)[C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 50995546Methyl 3-methyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate

Product 1

HCID 509955453-Methyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoic acidYield 74.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 3-methyl-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate (0.039 g; 0.099 mmol), sodium hydroxide 10N (0.100 mL; 0.1 mmol) in methanol (1 mL) to afford 0.028 g (73%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-c648c8fdddcc424a8ee1b71ae8bf836d
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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