Sodium Hydroxide → 2-[4-(2,4-Difluorophenyl)-6-methyl-2-(1-piperidyl)pyrimidin-5-yl]pentanoic acid

HRID 1399700Notes

Reaction equation

HRID 1399700 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:14]([CH:15]([CH2:20][CH2:21][CH3:22])[C:16]([O:18]C)=[O:17])=[C:13]([CH3:23])[N:12]=[C:11]([N:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[N:10]=1.[OH-].[Na+]>CO>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[C:14]([CH:15]([CH2:20][CH2:21][CH3:22])[C:16]([OH:18])=[O:17])=[C:13]([CH3:23])[N:12]=[C:11]([N:24]2[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]2)[N:10]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 50995373Methyl 2-(4-(2,4-difluorophenyl)-6-methyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate

Product 1

HCID 509955482-[4-(2,4-Difluorophenyl)-6-methyl-2-(1-piperidyl)pyrimidin-5-yl]pentanoic acidYield 72%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-(2,4-difluorophenyl)-6-methyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate (0.056 g; 0.139 mmol), sodium hydroxide 10N (0.200 mL; 2.00 mmol) in methanol (2 mL) at 60° C. for 18 h to afford 0.039 g (69%) of the title compound as a white solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-fe0daa13b07e4556858692d7dfa63f68
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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