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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1399702Erstellt: 25. Oktober 2026

Sodium Hydroxide → 2-[4-(2,4-Dimethylphenyl)-6-methyl-2-(1-piperidyl)pyrimidin-5-yl]pentanoic acid

https://huagongshe.com/reaction/1399702

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktSodium HydroxideHCID 14798—
EduktMethyl 2-(4-(2,4-dimethylphenyl)-6-methyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoateHCID 66955327—
LösungsmittelMethanolHCID 887—
Produkt2-[4-(2,4-Dimethylphenyl)-6-methyl-2-(1-piperidyl)pyrimidin-5-yl]pentanoic acidHCID 5099573089,3%

Reaktionsschritte

This compound was prepared according to general method D from 2 methyl 2-(4-(2,4-dimethylphenyl)-6-methyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate (0.073 g; 0.185 mmol), sodium hydroxide 10N (0.200 mL; 2.00 mmol) in methanol (2 mL) at 60° C. for 18 h to afford 0.063 g (88%) of the title compound as a white solid.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS08906906B2
Quelldatensatzuspto-grants-2014_12
ORD IDord-463eccf03c934df99f3eea72574f7ce1
Quellennotizuspto-grants-2014_12