Sodium Hydroxide → 2-(4-Methyl-2-(piperidin-1-yl)-6-(quinolin-5-yl)pyrimidin-5-yl)pentanoic acid

HRID 1399708Notes

Reaction equation

HRID 1399708 reaction equation
[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([O:11]C)=[O:10])=[C:6]([C:16]2[CH:25]=[CH:24][CH:23]=[C:22]3[C:17]=2[CH:18]=[CH:19][CH:20]=[N:21]3)[N:5]=[C:4]([N:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)[N:3]=1.[OH-].[Na+]>CO>[CH3:1][C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([OH:11])=[O:10])=[C:6]([C:16]2[CH:25]=[CH:24][CH:23]=[C:22]3[C:17]=2[CH:18]=[CH:19][CH:20]=[N:21]3)[N:5]=[C:4]([N:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)[N:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 50995731Methyl 2-(4-methyl-2-(piperidin-1-yl)-6-(quinolin-5-yl)pyrimidin-5-yl)pentanoate

Product 1

HCID 669563922-(4-Methyl-2-(piperidin-1-yl)-6-(quinolin-5-yl)pyrimidin-5-yl)pentanoic acidYield 93.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was prepared according to general method D from methyl 2-(4-methyl-2-(piperidin-1-yl)-6-(quinolin-5-yl)pyrimidin-5-yl)pentanoate (0.070 g; 0.167 mmol), sodium hydroxide 10N (0.200 mL; 2.00 mmol) in methanol (2 mL) at 60° C. for 18 h to afford 0.063 g (88%) of the title compound as a yellow solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-04ba2e5f82804d88a949bfb0f45122b5
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

Loading…