Sodium Hydroxide → 2-(4-Methyl-2-(piperidin-1-yl)-6-(quinolin-5-yl)pyrimidin-5-yl)pentanoic acid

Participants

Role	Name	HCID	Charge
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	Methyl 2-(4-methyl-2-(piperidin-1-yl)-6-(quinolin-5-yl)pyrimidin-5-yl)pentanoate	HCID 50995731	—
Solvent	Methanol	HCID 887	—
Product	2-(4-Methyl-2-(piperidin-1-yl)-6-(quinolin-5-yl)pyrimidin-5-yl)pentanoic acid	HCID 66956392	93.3%

Reaction Steps

This compound was prepared according to general method D from methyl 2-(4-methyl-2-(piperidin-1-yl)-6-(quinolin-5-yl)pyrimidin-5-yl)pentanoate (0.070 g; 0.167 mmol), sodium hydroxide 10N (0.200 mL; 2.00 mmol) in methanol (2 mL) at 60° C. for 18 h to afford 0.063 g (88%) of the title compound as a yellow solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08906906B2
Source dataset	uspto-grants-2014_12
ORD ID	ord-04ba2e5f82804d88a949bfb0f45122b5
Source note	uspto-grants-2014_12