1154740-54-1 → Methyl 2-(4-(5-chlorochroman-6-yl)-6-methyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate

HRID 1399772Notes

Reaction equation

HRID 1399772 reaction equation
Cl[C:2]1[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([O:11][CH3:12])=[O:10])=[C:6]([CH3:16])[N:5]=[C:4]([N:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)[N:3]=1.[Cl:23][C:24]1[C:33](B2OC(C)(C)C(C)(C)O2)=[CH:32][CH:31]=[C:30]2[C:25]=1[CH2:26][CH2:27][CH2:28][O:29]2>>[Cl:23][C:24]1[C:33]([C:2]2[C:7]([CH:8]([CH2:13][CH2:14][CH3:15])[C:9]([O:11][CH3:12])=[O:10])=[C:6]([CH3:16])[N:5]=[C:4]([N:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)[N:3]=2)=[CH:32][CH:31]=[C:30]2[C:25]=1[CH2:26][CH2:27][CH2:28][O:29]2

Participants

3

Reactant 2

HCID 596067631154740-54-1HCID 86665653Methyl 2-(4-chloro-6-methyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate

Product 1

HCID 66955735Methyl 2-(4-(5-chlorochroman-6-yl)-6-methyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate

Procedure

This compound is prepared according to general method E starting from methyl 2-(4-chloro-6-methyl-2-(piperidin-1-yl)pyrimidin-5-yl)pentanoate and 2-(5-chlorochroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-451349e9879e4a7da5409bb5ee6c02be
Source dataset
uspto-grants-2014_12
Patent number
US08906906B2

Reaction notes

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