反应详情

5-bromo-1H-pyrazole (146 mg, 1 mmol), methyl 4-(bromomethyl)benzoate (242 mg, 2 mmol) and K2C03 (276 mg, 2 mmol) were placed in a 100-mL flask with 2-butanone (20 mL) and heated at reflux temperature for 17 h. The mixture was cooled, filtered and evaporated in vacuuo leaving a residue which was dissolved in ethyl acetate and washed with water. The separated organic layer was dried and concentrated to give desired product as an oil (188 mg, 100% yield). This crude material was used without further purification. LCMS (m/z): 295.1 [M+H]+

1. temperatureheated
2. temperatureat reflux temperature for 17 h
3. temperatureThe mixture was cooled
4. filtrationfiltered
5. customevaporated in vacuuo
6. customleaving a residue which
7. washwashed with water
8. customThe separated organic layer was dried
9. concentrationconcentrated