Potassium Fluoride → HCID 86687909, compound

Participants

Reaction Steps

2-(5-Fluoro-2-((triethylsilyl)ethynyl)phenyl)acetonitrile (1.044 g, 3.82 mmol) is dissolved in methanol (38.2 ml), and potassium fluoride (0.887 g, 15.27 mmol) is added. The yellowish solution is stirred at RT for 48 hours. The solvent is subsequently removed in vacuo, and the residue is taken up with water (30 ml). The usual extraction and drying method described under 1) gives 606 mg of the title compound in quantitative yield. (3.81 mmol);

Provenance & Evidence